To generate a new sample sheet or make complex changes, use the Illumina Experiment Manager. a. If you have not installed IEM yet, select the Illumina Experiment Manager (IEM) link, and install IEM. b. Open IEM. c. Import the original sample sheet from your system in IEM and edit it, or generate a new sample sheet. See the Illumina Experiment Manager User Guide for instructions. d. Copy and paste the sample sheet into the Sample Sheet Editor in BaseSpace Sequence Hub. BaseSpace Sequence Hub validates the sample sheet and displays any errors above the sample sheet editor.